Target Synonym: PLAUR;CD87;U-PAR;UPAR;URKR;Monocyte activation antigen;suPAR;Urokinase Plasminogen Activator Surface Receptor;MO3;CD 87;CD87 antigen;MO 3;Monocyte activation antigen Mo3;Plasminogen activator receptor urokinase;Plasminogen activator urokinase receptor;U PAR;u plasminogen activator receptor;UPA receptor;u-plasminogen activator receptor form 2;Urinary plasminogen activator receptor;Urokinase plasminogen activator receptor;urokinase-type plasminogen activator (uPA) receptor
Background: This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined.
Immunogen: Recombinant Human CD87 protein
Buffer: PBS, pH 7.2. Contains 0.05% proclin 300.
Dilution: FCM 2 μg/mL(1×105-5×105 cells)
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