QC6352, CAS 1851373-36-8

Shelf life (days): 1460

Info: A KDM4 inhibitor; selective for KDM4A, KDM4B, KDM4C, and KDM4D (IC50s = 104, 56, 35, and 104 nM, respectively) over KDM2B, KDM3A, KDM3B, KDM6B, and PHF8 (IC50s = >4,000 nM for all) but does inhibit KDM5B (IC50 = 750 nM); increases H3K36Me3 levels in KYSE-150 cells (EC50 = 1.3 nM); reduces the proliferation of KYSE-150 cells (EC50 = 3.5 nM) but not IMR-90 fibroblasts (IC50 = >30 µM); reduces tumor volume in a BR0859f PDX mouse model of HER2-positive breast cancer at 10, 25, and 50 mg/kg

Formulation: A solid

Formal Name: 3-[[[(1R)-1,2,3,4-tetrahydro-6-(methylphenylamino)-1-naphthalenyl]methyl]amino]-4-pyridinecarboxylic acid

Purity: ≥98%

Formula Markup: C24H25N3O2

Formula Weight: 387.47432

CAS Number: 1851373-36-8

• Artikelnummer: CAY26231-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 26231-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK