Stock Concentration: 1000 µg/ml
Conjugate Type: Unconjugated
Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Shelf Life: 1 year from date of receipt
Protein Ref Seq ID: NP_002825.3
Uniprot ID: Q06124
Background: PTPN11/Shp2 is a src-homology 2-containing protein-tyrosine phosphatase (PTP). PTPN11/Shp2 is a non-receptor phosphatase that mediates a variety of cytokine, growth factor, and hormone signals. Signal transduction by PTPN11/Shp2 is achieved via the activation of the Ras/mitogen-activated protein kinase pathway. Heterogenous gain of function mutations in PTPN11/Shp2 are associated with juvenile myelomonocytic leukemia (JMML) and Noonan syndrome, a disorder characterized by short stature, facial dysmorphology, and congenital heart defects.
Immunogen: Between 543 and C-terminus
Physical State: Liquid
Formulation: BSA-Free
Purity: Antigen Affinity Purified
Antibody Registry ID: AB_1040019
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