Raloxifene 6-glucuronide, CAS 174264-50-7

Raloxifene 6-glucuronide, CAS 174264-50-7
Artikelnummer
MEXHY-135581-1
Verpackungseinheit
1 mg
Hersteller
MedChemExpress

Verfügbarkeit: wird geladen...
Preis wird geladen...
Product Description: Raloxifene 6-glucuronide is a primary metabolite of Raloxifene. Raloxifene 6-glucuronide is mediated mostly by UGT1A1 and UGT1A8. Raloxifene 6-glucuronide binds to estrogen receptor with an IC50 of 290 μM. Raloxifene is a selective and nonsteroidal estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression[1][2][3].

Applications: Metabolism-protein/nucleotide metabolism

Formula: C34H35NO10S

References: [1]Izgelov D, et al. The Effect of Piperine Pro-Nano Lipospheres on Direct Intestinal Phase II Metabolism: The Raloxifene Paradigm of Enhanced Oral Bioavailability. Mol Pharm. 2018 Apr 2;15(4):1548-1555./[2]Kemp DC, et al. Characterization of raloxifene glucuronidation in vitro: contribution of intestinal metabolism to presystemic clearance. Drug Metab Dispos. 2002 Jun;30(6):694-700./[3]Yang NN, et al. Estrogen and raloxifene stimulate transforming growth factor-beta 3 gene expression in rat bone: a potential mechanism for estrogen- or raloxifene-mediated bone maintenance. Endocrinology. 1996 May;137(5):2075-84.

CAS Number: 174264-50-7

Molecular Weight: 649.71

Research Area: Endocrinology

Solubility: 10 mM in DMSO

Target: Estrogen Receptor/ERR
Mehr Informationen
Artikelnummer MEXHY-135581-1
Hersteller MedChemExpress
Hersteller Artikelnummer HY-135581-1
Verpackungseinheit 1 mg
Mengeneinheit STK
Produktinformation (PDF)
×
MSDS (PDF)
×