Product Type: Agonist
CAS No.: 155141-29-0
MolecularFormula: C18H19N3O3S•C4H4O4
Molecular Weight: 473,5
Source: Synthetic
Purity: >98%
Solubility: Soluble in DMSO (3 mg/ml) or DMF (10 mg/ml)
Appearance: White to off-white solid
PubChem CID: 77999
Scientific Background: Rosiglitazone is a potent agonist for PPARγ with an EC50 of 43 nM for the human receptor. It is anti-diabetic, working as an insulin sensitizer by binding to the PPARγ receptors in fat cells and making the cells more responsive to insulin. It also rescues memory impairment in Alzheimer's Disease (8).
References: 1. Werner A.L., & Travaglini M.T. (2001) Pharmacotherapy. 21(9): 1082-99.2. McMorran M., and Vu D. (2001) CMAJ. 165(1): 82-3, 86-7.3. Malinowski J.M. & Bolesta S. (2000) Clin. Ther. 22(10): 1151-68.4. Cheng-Lai A., & Levine A. (2000) Heart Dis. 2(4): 326-33.5. Knock G.A., et al. (1999) Eur. J. Pharmacol. 368(1): 103-9.6. Balfour J.A., & Plosker G.L. (1999) Drugs. 57(6): 921-30.7. Parks D.J., et al. (1998) Bioorg. Med. Chem. Lett. 8(24): 3657-8. 8. Escribano L., et al. (2010) Neuropyschopharmacology. 35, 1593-1604.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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