Product Description: Safotibant (LF22-0542) is a selective antagonist for kinin B1 receptor (BKB1R), with Ki of 0.35 and 6.5 nM, for human and mouse BKB1R, respectively. Safotibant exhibits analgesic and anti-inflammatory property in mice model[1][2].
Applications: COVID-19-immunoregulation
Formula: C25H34N4O5S
References: [1]Sevcik MA, et al., Analgesic efficacy of bradykinin B1 antagonists in a murine bone cancer pain model. J Pain. 2005 Nov;6(11):771-5. /[2]Pouliot M, et al., Ocular application of the kinin B1 receptor antagonist LF22-0542 inhibits retinal inflammation and oxidative stress in streptozotocin-diabetic rats. PLoS One. 2012;7(3):e33864.
CAS Number: 633698-99-4
Molecular Weight: 502.63
Research Area: Inflammation/Immunology
Solubility: 10 mM in DMSO
Target: Bradykinin Receptor