SBI-115, CAS 882366-16-7

Formulation: A solid

Formal Name: 5-chloro-2-(ethylsulfonyl)-4-pyrimidinecarboxylic acid 3-methylphenyl ester

Purity: ≥98%

Formula Markup: C14H13ClN2O4S

Formula Weight: 340,8

Shelf life (days): 1460

CAS Number: 882366-16-7

Notes: SBI-115 is an antagonist of G protein-coupled bile acid receptor 1 (GPBAR1), also known as TGR5.{49821} It inhibits taurolithocholic acid-induced increases in cAMP levels in, and proliferation of, cholangiocytes isolated from patients with autosomal dominant polycystic kidney disease when used at concentrations of 100 and 200 µM. SBI-115 (10 µM) decreases the viability of, and protein levels of GPBAR1 in, PANC-1 pancreatic cancer cells.{49822} In vivo, SBI-115 (80 mg/kg) prevents B. pseudocatenulatum-induced decreases in serum levels of IFN-γ and IL-17A in a mouse model of collagen-induced arthritis.{49823}

• Artikelnummer: CAY39168-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 39168-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK