Shelf life (days): 1460
Info: An SST2 agonist; inhibits forskolin-induced cAMP accumulation in CCL-39 cells expressing recombinant human SST2 (EC50 = 0.093 nM) but also those expressing recombinant human SST3 or SST5 (EC50s = 209 and 0.47 nM, respectively); inhibits somatostatin-14-, somatostatin-25-, or somatostatin-28-induced developed tension in spontaneously beating guinea pig right atria (pA,2s = 6.5, 6.24, and 6.09, respectively); selectively binds to SST2, SST3, and SST5 (Kds = 0.15, 21, and 0.06 nM, respectively) over SST1 and SST4 (Kds = 13.5 and 9.1 µM, respectively); inhibits gastrin-, dimaprit-, or IBMX-induced acid secretion is isolated rat gastric mucosa (EC50s = 6, 17, and 13 nM, respectively); increases extracellular dopamine levels in the ipsilateral nucleus accumbens in rats
Formulation: A solid
Formal Name: cyclo(N-methyl-L-alanyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-phenylalanyl), acetate
Amino Acids: cyclo(XYwKVF) (X=N-methylalanine)
Purity: ≥98%
Formula Markup: C44H56N8O7 • XC2H4O2
Formula Weight: 808.96516
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