Product Description: Seglitide (MK-678) is a potent, orally active somatostatin receptor 2 (SSTR2) agonist, and also a competitive antagonist of SSTR14, SSTR25, and SSTR28. Seglitide has antihypertensive effects and can inhibit plasma glucagon and growth hormone. Seglitide can be used for research on diabetes[1][2][3].
Applications: Neuroscience-Neuromodulation
Formula: C44H56N8O7
References: [1]Dimech J, et al. Antagonist effects of seglitide (MK 678) at somatostatin receptors in guinea-pig isolated right atria. Br J Pharmacol. 1993;109(4):898-899./[2]Bhattarai J P, Kaszas A, Park S A, et al. Somatostatin inhibition of gonadotropin-releasing hormone neurons in female and male mice[J]. Endocrinology, 2010, 151(7): 3258-3266./[3]Hartmann J, et al. Blood pressure reduction in hypertensive-diabetic rats by the somatostatin analog MK-678. Life Sci. 1989;45(3):267-74.
CAS Number: 81377-02-8
Molecular Weight: 808.96
Compound Purity: 99.30
Research Area: Metabolic Disease; Neurological Disease; Cardiovascular Disease
Solubility: 10 mM in DMSO
Target: Somatostatin Receptor
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