Shelf life (days): 1460
Info: An NCX1 inhibitor (IC50 = 2.9 µM); selective for NCX1 over NCX2, NCX3, and NCKX2 (IC50s = 16, 8.6, and >30 µM, respectively) and a panel of 26 additional ion channels and receptors at 30 µM; inhibits bidirectional inward and outward currents and unidirectional outward currents in whole-cell voltage-clamp assays using isolated guinea pig ventricular myocytes (IC50s = 1.9, 2.3, and 0.6 µM, respectively); reduces hypoxia-reoxygenation-induced LDH release in LLC-PK1 cells overexpressing NCX1 (IC50 = 0.63 µM); decreases ethanol intake and preference in female rats at 10 mg/kg; decreases the incidence of clonic and tonic-clonic seizures induced by PTZ in rats from 1-30 mg/kg
Formulation: A solid
Formal Name: 2-[[4-[(4-nitrophenyl)methoxy]phenyl]methyl]-4-thiazolidinecarboxylic acid, ethyl ester
Purity: ≥98%
Formula Markup: C20H22N2O5S
Formula Weight: 402.46516
CAS Number: 415697-08-4
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