Description: TAT-PiET, a cell-penetrating peptide, targets the extra-terminal (ET) domain of BRD4, disrupting the critical BRD4/JMJD6 protein complex interaction necessary for oncogene expression in breast cancer. By inhibiting BRD4/JMJD6 target gene expression, TAT-PiET effectively suppresses breast cancer cell growth and confers resistance to endocrine therapy in ERα-positive breast cancer cells, marking it as a potential inhibitor of breast cancer.
CAS Number: 3036046-03-1
Formula: C110H192N48O27S
Molecular Weight: 2651,07