Shelf life (days): 730
Info: A PI3Kγ and PI3Kδ inhibitor (IC50s = 0.083 and 0.235 µM, respectively); selective for PI3Kγ and PI3Kδ over PI3Kα and PI3Kβ (IC50s = 1.3 and 1.2 µM); inhibits TRPM7 kinase activity (IC50 = 1.07 µM); inhibits the migration and invasion of MDA-MB-231 breast cancer cells at 50 µM; prevents VEGF- or histamine-induced intradermal edema and PAF- or dextran-induced hind paw edema and leukocyte infiltration in rats at 1 and 5 mg/kg, respectively; decreases infarct size as a percentage of the area at risk in a porcine model of myocardial infarction induced by coronary artery occlusion at 0.5 mg/kg
Formulation: A crystalline solid
Formal Name: 3,3’-(2,4-diamino-6,7-pteridinediyl)bis-phenol
Purity: ≥95%
Formula Markup: C18H14N6O2
Formula Weight: 346.3
CAS Number: 677297-51-7