Clone Name: 4F14
Application Note: WB: 1:100 - 1:1000. IHC-P: 1:50 - 1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 65
Specificity/Sensitivity: No cross reactivity was found to TGF beta receptor 3
Form: Liquid
Buffer (with preservative): PBS, no preservative.
Concentration: 200 μg/ml (Please refer to the vial label for the specific concentration.)
Background: The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Aug 2017]
Uniprot ID: P37173
Antigen Species: Human
Immunogen: Recombinant hu-TGFβRII extra cellular domain
Purification: Protein G purified
Conjugation: Unconjugated
Full Name: transforming growth factor beta receptor 2
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