Target: TNFR1
Conjugate: RPE
Product Type: Polyclonal
Immunogen: Peptide corresponding to AA 20-43 of the mouse TNF-R1 sequence, identical to rat and human over those residues
Swiss-Prot: P19438
Purification: Peptide Affinity Purified
Storage Buffer: 95.64mM Phosphate, 2.48mM MES and 2mM EDTA
Concentration: 1 mg/ml
Specificity: Detects ~55kDa. Other bands present may be the result of oligomerization, self-aggregation and/or cleavage of the TNF-R1 extracellular domain.
Cellular Localization: Cell Membrane / Golgi Apparatus / Golgi Apparatus Membrane
Scientific Background: The Tumor Necrosis Factor Receptor (TNFR) also known as Cluster of differentiation (CD120) is a protein that belongs to the (TNF)/ (TNFR) superfamily. TNF interacts with two distinct receptors TNFR1 and TNFR2. These receptors share no homology on their cytoplasmic sequences(1,3).TNFR1 also known as p55/p60 is a high affinity receptor for TNF-α. The TNFR1 has an extracellular domain with variable numbers of cysteine-rich repeats. The functional properties of TNFR1 are targets in new therapies for osteoporosis, chronic inflammatory and autoimmune diseases (1, 2). The TNF-α/TNFR1 receptor complex is responsible for the recruitment and the subsequent activation of the caspase (aspartate-specific cysteine proteases) that regulate apoptosis.
References: 1. Kontermann R.E., et al. (2008) J Immunother. 31(3):225-34.2. Hehlgans T. and Pfeffer K. (2005) Immunology. 115(1):1-20.3. Al-Lamki S., et al. (2005) The Faseb Journal. 19:1638-1645.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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