Product Description: trans-J-113863 is a potent chemokine CCR1 and CCR3 receptor antagonist, and inhibits MIP-1α-induced chemotaxis in CCR1 transfectants and eotaxin-induced chemotaxis in CCR3 transfectants with IC50s of 9.57 and 93.8 nM,respectively[1][2].
Applications: COVID-19-immunoregulation
Formula: C30H37Cl2IN2O2
References: [1]Sabroe I, et al. A small molecule antagonist of chemokine receptors CCR1 and CCR3. Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry. J Biol Chem. 2000;275(34):25985-25992./[2]de Mendonça FL, et al. Site-directed mutagenesis of CC chemokine receptor 1 reveals the mechanism of action of UCB 35625, a small molecule chemokine receptor antagonist. J Biol Chem. 2005;280(6):4808-4816.
CAS Number: 202796-42-7
Molecular Weight: 655.44
Research Area: Inflammation/Immunology
Solubility: 10 mM in DMSO
Target: CCR
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