Urotensin-II receptor antagonist-1, CAS 1034708-07-0

Product Description: Urotensin-II receptor antagonist-1 (compound 1) is a low oral bioavailability (F=0-3%, rat) selective human Urotensin II receptor antagonist, Ki=16 nM (test on HEK293 cells expressing recombinant human UT receptor). Urotensin-II receptor antagonist-1 inhibits cytochrome P450 (IC50=0.75 μM, CYP2D6; 1.4 μM, CYP3A4), inhibits κ-opioid receptor (EC50=3.2 μM), targets cardiac sodium channels (Ki=2.5 μM)[1].

Applications: Neuroscience-Neuromodulation

Formula: C25H31Cl2N3O

References: [1]McAtee JJ, et al. Development of potent and selective small-molecule human Urotensin-II antagonists. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3500-3.

CAS Number: 1034708-07-0

Molecular Weight: 460.44

Research Area: Cardiovascular Disease

Target: Cytochrome P450;Opioid Receptor;Sodium Channel;Urotensin Receptor

• Artikelnummer: MEXHY-10672-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-10672-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK