Vitamin D3 Receptor

Vitamin D3 Receptor, IgG2b, Host: Rat, Monoclonal, Clone: 9A7

Clone: 9A7.

Background: The antibody to VDR labels the nuclear receptor in a number of tissues like intestine, bone, kidney, epidermis, and endocrine cells. 1,25(OH)2-Vitamin D3, the active form of vitamin D binds to a nuclear receptor (Vitamin D receptor, VDR), which is acting as a transcription factor in calcium and bone metabolism. Many effects of vitamin D3 are due to VDR regulated transcription of certain target gens, which are involved in cell proliferation, differentiation and apoptosis. Vitamin D receptor, detects epitope aa 89-105 in human VDR.

Positive Control: Intestine, skin, kidney.

Immunogen: Partially purified chicken vitamin D receptor.

References: 1. Nemere I, Ray R, McManus W. (2000) Immunochemical studies on the putative plasmalemmal receptor for 1,25(OH)(2)D(3). I. Chick intestine. Am J Physiol Endocrinol Metab. 2000 Jun;278(6):E1104-142. Bischoff HA, Borchers M, Gudat F, Duermueller U, Theiler R, Stahelin HB, Dick W. (2001) In situ detection of 1,25-dihydroxyvitamin D3 receptor in human skeletal muscle tissue. Histochem J. 2001 Jan;33(1):19-243. Balmain N, Hauchecorne M, Pike JW, Cuisinier-Gleizes P, Mathieu H. (1993) Distribution and subcellular immunolocalization of 1,25-dihydroxyvitamin D3 receptors in rat epiphyseal cartilage. Cell Mol Biol (Noisy-le-grand). 1993 May;39(3):339-50.

Caution: These antibodies are intended for in vitro research use only. They must not be used for clinical diagnostics and not for in vivo experiments in humans or animals.

• Artikelnummer: BILVDR001
• Hersteller: BioLogo
• Hersteller Artikelnummer: VDR001
• Verpackungseinheit: 100 µl
• Mengeneinheit: STK
• Reaktivität: Mammalian, Chicken, Bird (Avian)
• Klonalität: Monoclonal
• Methode: Immunohistochemistry (paraffin), Immunoprecipitation, Western Blotting, Functional Inhibition
• Isotyp: IgG2b
• Wirt: Rat