Target: VPS35
Product Type: ELISA Kits
Trademark: MOLECULAR SIGNATURE®
Detection Method: Colorimetric Assay
Assay Type: Sandwich ELISA (Enzyme-linked Immunosorbent Assay)
Utility: ELISA kit used to quantitate VPS35 in samples.
Sample Type(s): Tissue / Cell Lysate
Number of Samples: 40 samples in duplicate
Incubation Time: 3 hours
Sensitivity: 50 pg/mL
Assay Range: 78.125 - 5000 pg/mL
Scientific Background: Vacuolar Protein Sorter-35 (VPS35) is a component of the retromer complex, which is essential for endosome-to-Golgi retrieval of membrane proteins. VPS35 mutations such as D620N have been linked to Parkinson’s Disease (PD) (1,2) and affect retromer function, protein homeostasis, and mitochondria (3).
References: 1. Vilarino-Guell, C. et al. (2011) Am J Hum Genet 89:162–1672. Zimprich, A. et al. (2011) Am J Hum Genet 89:168–1753. Rahman, A.A., Morrison, B.E. (2019) Neurosci 401:1-10.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Deutsch
English
