VU0360172 (hydrochloride), CAS 1309976-62-2

Product Description: VU0360172 hydrochloride is a potent and selective mGlu5 receptor positive allosteric modulator (PAM) with an EC50 value of 16 nM and a Ki of 195 nM, respectively. VU0360172 hydrochloride stimulates polyphosphoinositide (PI) hydrolysis in vivo, which is abrogated in mGlu5 receptors gene deleted mice[1].

Applications: Neuroscience-Neuromodulation

Formula: C18H16ClFN2O

References: [1]Alice L Rodriguez, et al. Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol Pharmacol. 2010 Dec;78(6):1105-23.

CAS Number: 1309976-62-2

Molecular Weight: 330.78

Compound Purity: 98.94

Research Area: Neurological Disease

Solubility: 10 mM in DMSO

Target: mGluR

• Artikelnummer: MEXHY-107504-50
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-107504-50
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK