Product Description: VVD-130037 (BAY-3605349) is an orally active covalent activator of KEAP 1 (Kelch-like ECH-associated protein 1) with anti-tumor activity. VVD-130037 degrades NRF2 (nuclear factor-erythroid 2 p45-related factor 2), resulting in significant inhibition of tumor growth in advanced solid tumors[1][2][3].
Applications: Cancer-programmed cell death
Formula: C17H17ClN4O2
References: [1]Chan Shan, et al. The Crosstalk between Autophagy and Nrf2 Signaling in Cancer: from Biology to Clinical Applications. Int J Biol Sci. 2024 Nov 11;20(15):6181-6206./[2]Gu X, et al. The Cancer Antioxidant Regulation System in Therapeutic Resistance. Antioxidants (Basel). 2024 Jun 27;13(7):778./[3]Han B, et al. Tumor suppressor KEAP1 promotes HSPA9 degradation, controlling mitochondrial biogenesis in breast cancer. Cell Rep. 2024 Jul 23;43https://pubmed.ncbi.nlm.nih.gov/39003742/(7):114507.
CAS Number: 3034880-93-5
Molecular Weight: 344.80
Compound Purity: 99.91
Research Area: Cancer
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: Keap1-Nrf2
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