Product Description: Xanthomicrol is extracted from the resin of the plant called Chinese bellflower (a member of the Scrophulariaceae family) and is a monoamine oxidase (MAOs) inhibitor. Xanthomicrol has anti-tumor and anti-inflammatory properties, with IC50 values of 0.88 and 1.69 μg/mL in HL60 and K562 cells. Xanthomicrol's the main metabolite of 5DT in mouse colon, and it can reduce levels of iNOS protein and mRNA, as well as COX-2 protein levels. Additionally, Xanthomicrol decreases the production of the pro-inflammatory cytokine IL-1β and induces the expression of the antioxidant enzyme HO-1[1][2][3][4][5].
Applications: COVID-19-immunoregulation
Formula: C18H16O7
References: [1]F. A. TOMAS-BARBERAN, et al. Epicuticular Flavonoids from Beffardia trixago and their Antifungal Fully Methylated Derivatives. Int. J. Crude Drug Res., 28 (l990), No. I, pp. 57-60./[2]Fereshteh Jahaniani, et al. Xanthomicrol is the main cytotoxic component of Dracocephalum kotschyii and a potential anti-cancer agent. Phytochemistry. 2005 Jul;66(13):1581-92./[3]Shanshan Guo, et al. Anti-inflammatory effect of xanthomicrol, a major colonic metabolite of 5-demethyltangeretin. Food & Function. 30-Apr-2018./[4]Fatma Pinar Turkmenoglu, et al. Flavonoids from Sideritis Species: Human Monoamine Oxidase (hMAO) Inhibitory Activities, Molecular Docking Studies and Crystal Structure of Xanthomicrol. Molecules. 2015 Apr 23;20(5):7454-73./[5]Shanshan Guo, et al. Identification of xanthomicrol as a major colonic metabolite of 5-demethyltangeretin in mice and their anti-inflammatory effects in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Food & Function. 30-Apr-2018.
CAS Number: 16545-23-6
Molecular Weight: 344.32
Compound Purity: 95.0
Research Area: Cancer; Inflammation/Immunology
Target: COX;Interleukin Related;NO Synthase;Reactive Oxygen Species
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