Product Description: Zorevunersen sodium is an antisense oligonucleotide that is intended to increase the level of productive SCN1A mRNA and consequently increase the expression of the sodium channel Nav1.1 protein. Zorevunersen sodium is used for the study of Dravet syndrome.
Applications: Neuroscience-Neuromodulation
Formula: C234H317N71Na17O124P17S17
References: [1]Wengert ER, Wagley PK, Strohm SM, et al. Targeted Augmentation of Nuclear Gene Output (TANGO) of Scn1a rescues parvalbumin interneuron excitability and reduces seizures in a mouse model of Dravet Syndrome. Brain Res. 2022;1775:147743. /[2]Bialer M, Johannessen SI, Koepp MJ, et al. Progress report on new antiepileptic drugs: A summary of the Sixteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVI): II. Drugs in more advanced clinical development. Epilepsia. 2022;63(11):2883-2910.
CAS Number: 2415330-05-9
Molecular Weight: 7197.27
Compound Purity: 98.25
Research Area: Others
Solubility: H2O : ≥ 20 mg/mL
Target: Sodium Channel
Deutsch
English
