1-EBIO, CAS 10045-45-1

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 1-ethyl-1,3-dihydro-2H-benzimidazol-2-one

Purity: ≥98%

Formula Markup: C9H10N2O

Formula Weight: 162.2

CAS Number: 10045-45-1

Notes: 1-EBIO is an activator of Ca2+-sensitive K+ channels (EC50 = 490 µM in T84 human carcinoma cells).{23032} This action is sensitive to the neurotoxin charybdotoxin (Ki = 3.5 nM). In mouse colonic epithelia, 1-EBIO also activates cAMP-sensitive K+ channels, a response this is inhibited by 293B.{23033} In this type of epithelium, but not mouse nasal epithelia, 1-EBIO activates both types of channels, resulting in large Cl- secretory currents.{23029} It also activates the human intermediate conductance Ca2+-activated K+ channel (EC50 = 74 µM).{23030} 1-EBIO is currently used to study the role of these types of K+ channels in diverse physiological functions.{23031,23028}

• Artikelnummer: CAY14575-100
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 14575-100
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK