1-Methylpseudouridine, CAS 13860-38-3

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 1-methyl-5-ß-D-ribofuranosyl-2,4(1H,3H)-pyrimidinedione

Purity: ≥98%

Formula Markup: C10H14N2O6

Formula Weight: 258.22804

CAS Number: 13860-38-3

Notes: 1-Methylpseudouridine is a nucleoside analog that has been found in Streptomyces platensis.{65154} It increases the thermodynamic and biological stability of RNA.{65155,65156,65157} Unlike unmodified mRNA, 1-methylpseudouridine-containing mRNA does not induce IFN-β secretion in A549 cells, indicating low immunogenicity.{65156} Intramuscular or intradermal administration of luciferase mRNA containing 1-methylpseudouridine via lipid complexes increases luciferase activity in mice. Formulations containing 1-methylpseudouridine incorporated into mRNA have been used in the development of mRNA-based vaccines.

• Artikelnummer: CAY35401-250
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 35401-250
• Verpackungseinheit: 250 mg
• Mengeneinheit: STK
• Methode: Reinstoffe