Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (3aS,4S,7aR)-5-[(1S)-4-(acetyloxy)-1-methylbutyl]-3a,4,7,7a-tetrahydro-4-hydroxy-6-methyl-3-methylene-2(3H)-benzofuranone
Purity: ≥98%
Formula Markup: C17H24O5
Formula Weight: 308.36946
CAS Number: 33627-41-7
Notes: 1-O-Acetylbritannilactone is a sesquiterpene lactone that has been found in I. britannica and has diverse biological activities.{60843,60844} It inhibits LPS-induced production of prostaglandin E2 (PGE2; Item No. 14010) and nuclear translocation of NF-κB in primary rat aorta vascular smooth muscle cells (VSMCs).{60843} 1-O-Acetylbritannilactone (5 and 10 µM) inhibits VEGF-induced capillary tube formation in human umbilical vein endothelial cells (HUVECs).{60844} It reduces tumor growth in an A549 mouse xenograft model when administered at a dose of 12 mg/kg per day.
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