Product Description: 1400W dihydrochloride is the dihydrochloride form of 1400W (HY-18730). 1400W is a slow, tight binding, and highly selective inducible nitric-oxide synthase (iNOS) inhibitor, with a Kd value ≤ 7 nM. 1400W inhibits iNOS induction in microglial cells, and reduces generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex, and improving the spatial memory dysfunction caused by acute hypobaric hypoxia-reoxygenation[1][2].
Applications: COVID-19-immunoregulation
Formula: C10H17Cl2N3
Citations: Biomed Pharmacother. 2022 Jul;151:113098./Biomed Pharmacother. 2022 Sep;153:113532./Cell Metab. 2025 Jan 7;37(1):291-304.e9./Cell Rep. 2022 Feb 15;38(7):110391./Int J Biol Sci. 2020 Mar 5;16(9):1563-1574./Int J Ophthalmol. 2022 Jul 18;15(7):1053-1061./iScience. 2023 Jul 7./J Physiol. 2024 Jul 26./J Transl Med. 2023 Nov 25;21(1):852./Microvasc Res. 2022: 104468./Mol Cell. 2020 Jan 2;77(1):95-107.e5. /Mucosal Immunol. 2024 Feb 20:S1933-0219(24)00015-1./Redox Biol. 2023 Sep 27, 102905./Sci Total Environ. 2020 Jan 1;698:134294./Skelet Muscle. 2022 Jul 29;12(1):19./ISME J. 2024 Jan 28:wrae014.
References: [1]Garvey EP, et al. 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J Biol Chem. 1997 Feb 21;272(8):4959-63./[2]Shi Q, et al. 1400W ameliorates acute hypobaric hypoxia/reoxygenation-induced cognitive deficits by suppressing the induction of inducible nitric oxide synthase in rat cerebral cortex microglia. Behav Brain Res. 2017 Feb 15;319:188-199.
CAS Number: 214358-33-5
Molecular Weight: 250.17
Compound Purity: 99.94
Research Area: Cancer; Inflammation/Immunology; Cardiovascular Disease
Solubility: DMSO : 20 mg/mL (ultrasonic)/H2O : 100 mg/mL (ultrasonic)
Target: Apoptosis;NO Synthase
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