2-Amino-3-methylimidazo(4,5-f)quinoline, CAS 76180-96-6

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 3-methyl-3H-imidazo[4,5-f]quinolin-2-amine

Purity: ≥98%

Formula Markup: C11H10N4

Formula Weight: 198.2

CAS Number: 76180-96-6

Notes: 2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) is a food-derived carcinogen that is found in high temperature-cooked meats and tobacco smoke.{39298} In humans, IQ is metabolized by the cytochrome (CYP) P450 isoform CYP1A2 and conjugated by N-acetyltransferase or sulfotransferase to a metabolite that reacts with DNA to form adducts. It induces formation of single-base substitutions and exon deletions and increases cell death in vitro in a concentration-dependent manner. In vivo, IQ increases the incidence of squamous cell hyperplasias in the stomach of p53 knockout mice and increases hepatocellular lesions in female mice regardless of p53 status.{39299}

• Artikelnummer: CAY21853-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 21853-50
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK