2-D08, CAS 144707-18-6

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 2-(2,3,4-trihydroxyphenyl)-4H-1-benzopyran-4-one

Purity: ≥98%

Formula Markup: C15H10O5

Formula Weight: 270.2

CAS Number: 144707-18-6

Notes: 2-D08 is a synthetic flavone that inhibits sumoylation.{38137} It completely inhibits sumoylation in microfluidic electrophoretic mobility shift and kinetic assays at a concentration of 30 µM. 2-D08 inhibits sumoylation of topoisomerase I in the breast cancer cell lines ZR-75-1 and BT-474.{38136} It specifically disrupts the transfer of SUMO from the E2 enzyme (UBC9) thioester conjugate to the substrate. 2-D08 prevents amyloid-β (Aβ) (1-42) aggregation and Aβ-induced toxicity in PC12 cells.{38138} It also has antioxidant properties.{38135}

• Artikelnummer: CAY20459-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 20459-25
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK