Product Description: (2S,3R,4S)-4-Hydroxyisoleucine is an orally active compound. (2S,3R,4S)-4-Hydroxyisoleucine can be isolated from Trigonella foenum-graecum. (2S,3R,4S)-4-Hydroxyisoleucine has anti-diabetic and anti-diabetic nephropathy activity[1][2][3].
Applications: Metabolism-protein/nucleotide metabolism
Formula: C6H13NO3
References: [1]Shi X, et al. Engineering a short-chain dehydrogenase/reductase for the stereoselective production of (2S,3R,4S)-4-hydroxyisoleucine with three asymmetric centers. Sci Rep. 2017 Oct 20;7(1):13703./[2]Broca C, et al. 4-Hydroxyisoleucine: effects of synthetic and natural analogues on insulin secretion. Eur J Pharmacol. 2000 Mar 3;390(3):339-45./[3]Haeri MR, et al. Non-insulin dependent anti-diabetic activity of (2S, 3R, 4S) 4-hydroxyisoleucine of fenugreek (Trigonella foenum graecum) in streptozotocin-induced type I diabetic rats. Phytomedicine. 2012 May 15;19(7):571-4.
CAS Number: 55399-93-4
Molecular Weight: 147.17
Compound Purity: 98.0
Research Area: Metabolic Disease
Solubility: H2O : 50 mg/mL (ultrasonic)
Target: Insulin Receptor
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