3-Deazauridine, CAS 23205-42-7

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 4-hydroxy-1-ß-D-ribofuranosyl-2(1H)-pyridinone

Purity: ≥98%

Formula Markup: C10H13NO6

Formula Weight: 243.2

CAS Number: 23205-42-7

Notes: 3-Deazauridine is a nucleoside analog.{41307} It is converted intracellularly to 3-deazauridine triphosphate, which competitively inhibits cytidine triphosphate synthetase thereby inhibiting biosynthesis of the nucleic acid cytidine 5’-triphosphate (CTP). 3-Deazauridine inhibits the growth of L1210 leukemia cells when used at a concentration of 6 µM and dose-dependently reduces mortality in a mouse model of leukemia.{41306} It also enhances the incorporation of decitabine (Item No. 11166) into DNA in HL-60 myeloid and MOLT-3 lymphoid leukemia cells when used at a concentration of 20 µM. 3-Deazauridine (100 or 150 mg/kg), when combined with decitabine, reduces mortality in an L1210 leukemia mouse model.{41308}

• Artikelnummer: CAY23125-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 23125-10
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK