Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: S-(hydrogen 3-hydroxy-3-methyl-d3-pentanedioate)-coenzyme A, tetraammonium salt
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C27H37D3N7O20P3S / 4NH4
Formula Weight: 982.801143
Notes: 3-hydroxy-3-methylglutaryl-Coenzyme A-d3 is intended for use as an internal standard for the quantification of 3-hydroxy-3-methylglutaryl-coenzyme A (Item No. 25394) by GC- or LC-MS. 3-hydroxy-3-methylglutaryl-Coenzyme A (HMG-CoA) is an intermediate in several metabolic pathways.{42966,15099,37635,20949} Conversion of HMG-CoA to mevalonate by HMG-CoA reductase is the rate-limiting first step in the cholesterol biosynthetic pathway.{37635,15099} Alternatively, HMG-CoA can be cleaved into acetyl-CoA and the ketone body acetoacetate in mitochondria by HMG-CoA lyase.{20949,42966} HMG-CoA is also an intermediate in the degradation of leucine.{20949}
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