Product Description: 3-Hydroxykynurenine, a metabolite of tryptophan, is a potential endogenous neurotoxin whose increased levels have been described in several neurodegenerative disorders. 3-Hydroxykynurenine induces neuronal apoptosis[1].
Applications: Neuroscience-Neuromodulation
Formula: C10H12N2O4
References: [1]S Okuda, et al. 3-Hydroxykynurenine, an endogenous oxidative stress generator, causes neuronal cell death with apoptotic features and region selectivity. J Neurochem. 1998 Jan;70(1):299-307./[2]Sarah S Zaher,et al. 3-hydroxykynurenine suppresses CD4+ T-cell proliferation, induces T-regulatory-cell development, and prolongs corneal allograft survival. Invest Ophthalmol Vis Sci. 2011 Apr 22;52(5):2640-8.
CAS Number: 484-78-6
Molecular Weight: 224.21
Compound Purity: 99.90
Research Area: Neurological Disease
Solubility: 1M HCl : 33.33 mg/mL (ultrasonic;adjust pH to 1 with HCl)/DMSO : 1 mg/mL (ultrasonic;warming;heat to 60°C)
Target: Apoptosis;Endogenous Metabolite
Deutsch
English
