4′-DTMP, CAS 21253-58-7

Product Description: 4 '-DTMP is a DHFR inhibitor with Ki of 5.1 nM (DHFRWT) and 34.3 nM (DHFRL28R), respectively. 4 '-DTMP carries a polar modification that induces additional local interactions with the enzyme. In particular, the hairpin structure on the M20 ring is related to the internal communication of the DHFR. 4 '-DTMP has potential inhibition of E.coli[1].

Applications: COVID-19-immunoregulation

Formula: C13H16N4O3

References: [1]Cetin E, et al. Kinetic Barrier to Enzyme Inhibition Is Manipulated by Dynamical Local Interactions in E. coli DHFR. J Chem Inf Model. 2023 Aug 14;63(15):4839-4849.

CAS Number: 21253-58-7

Molecular Weight: 276.296

Compound Purity: 97.0

Research Area: Infection

Solubility: DMSO : 50 mg/mL (ultrasonic)

Target: Dihydrofolate reductase (DHFR)

• Artikelnummer: MEXHY-W587663-10.1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-W587663-10.1
• Verpackungseinheit: 10mM/1mL
• Mengeneinheit: STK