Product Description: 4-Epianhydrochlortetracycline hydrochloride is an inhibitor of matrix metalloproteinases (MMPs), particularly gelatinase B (Gelatinase B, EC 3.4.24.35), with inhibition rates of 100% at 500 μg/mL, 70% at 125 μg/mL, and 40% at 31 μg/mL. 4-Epianhydrochlortetracycline hydrochloride is promising for research in chronic inflammatory diseases[1].
Formula: C22H22Cl2N2O7
References: [1]Paemen L, et al. The gelatinase inhibitory activity of tetracyclines and chemically modified tetracycline analogues as measured by a novel microtiter assay for inhibitors. Biochem Pharmacol. 1996 Jul 12;52(1):105-11.
CAS Number: 158018-53-2
Molecular Weight: 497.33
Research Area: Inflammation/Immunology
Target: MMP