Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 2-amino-2,3,5-trideoxy-3-methyl-L-ribonic acid
Purity: ≥95%
Formula Markup: C6H13NO3
Formula Weight: 147.2
CAS Number: 55399-93-4
Notes: 4-Hydroxyisoleucine is an amino acid that has been found in fenugreek (T. foenum graecum) seeds and has antidiabetic activity.{51117,51118,51119} It increases glucose-stimulated insulin release from isolated rat islets and isolated perfused rat pancreas when used at a concentration of 200 μM.{51117} In vivo, 4-hydroxyisoleucine increases PI3K activity in muscle and liver in rats when administered at a dose of 18 mg/kg and in muscle in a rat model of type 2 diabetes induced by nicotinamide (Item No. 11127) and streptozotocin (STZ; Item No. 13104) when administered at 25 mg/kg.{51118} 4-Hydroxyisoleucine (50 mg/kg per day for four weeks) decreases plasma glucose, triglyceride, LDL, HDL, and cholesterol levels in an STZ-induced rat model of type 1 diabetes.{51119}
Deutsch
English
