Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 7-[[2-deoxy-2-(sulfoamino)-a-D-glucopyranosyl]oxy]-4-methyl-2H-1-benzopyran-2-one, monosodium salt
Purity: ≥98%
Formula Markup: C16H18NO10S / Na
Formula Weight: 439.37063
CAS Number: 460085-45-4
Notes: 4-Methylumbelliferyl 2-sulfamino-2-deoxy-α-D-Glucopyranoside (4-MU-α-GlcNS) is a fluorogenic substrate of heparin sulphamidase.{39610} Heparin sulphamidase cleaves 4-MU-α-GlcNS to yield 4-MU-α-GlcNH2, which is then cleaved by α-glucosaminidase to release the fluorescent product 4-MU, which displays an emission maxima of 445-454 nm.{39610,27251} The excitation maxima for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively.{27251} 4-MU-α-GlcNS has been used to quantify heparin sulphamidase deficiencies associated with Mucopolisaccaridosis IIIA and other lysosomal disorders.{39611}
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