Product Description: 5-Acetamide-Butenolide (Butenolide) is a mycotoxin with pro-oxidant activity, which is found in Fusarium. 5-Acetamide-Butenolide disrupts the mitochondrial membrane potential in primary neonatal rat cardiomyocytes. 5-Acetamide-Butenolide also induces the production of thiobarbituric acid reactive substances (TBARS) in isolated rat myocardial mitochondria. 5-Acetamide-Butenolide increases the production of reactive oxygen species (ROS), decreases the levels of GSH and reduces the viability of HepG2 cells[1][2][3].
Applications: Metabolism-sugar/lipid metabolism
Formula: C6H7NO3
References: [1]Yates S G, et al. Mycotoxins produced by Fusarium nivale isolated from tall fescue (Festuca arundinacea Schreb.)[J]. Phytochemistry, 1968, 7(1): 139-146./[2]Wang YM, et al. Effects of Fusarium mycotoxin butenolide on myocardial mitochondria in vitro. Toxicol Mech Methods. 2009 Feb;19(2):79-85./[3]Wang YM, et al. Depletion of intracellular glutathione mediates butenolide-induced cytotoxicity in HepG2 cells. Toxicol Lett. 2006 Jul 14;164(3):231-8.
CAS Number: 16275-44-8
Molecular Weight: 141.12
Research Area: Metabolic Disease
Target: Mitochondrial Metabolism;Reactive Oxygen Species
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