5-Azacytidine, CAS 320-67-2

Product Description: 5-Azacytidine (Azacitidine; 5-AzaC; Ladakamycin) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation. 5-Azacytidine is incorporated into DNA to covalently trap DNA methyltransferases and contributes to reverse epigenetic changes[1][2]. 5-Azacytidine induces cell autophagy[4].

Applications: Cancer-programmed cell death

Formula: C8H12N4O5

References: [1]Christman JK. 5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. Oncogene. 2002 Aug 12;21(35):5483-95./[2]Creusot F, et al. Inhibition of DNA methyltransferase and induction of Friend erythroleukemia cell differentiation by 5-azacytidineand 5-aza-2'-deoxycytidine. J Biol Chem. 1982 Feb 25;257(4):2041-8./[3]Li LH,et al. Cytotoxicity and mode of action of 5-azacytidine on L1210 leukemia. Cancer Res. 1970 Nov;30(11):2760-9./[4]Marycz K, et al. 5-Azacytidine and Resveratrol Enhance Chondrogenic Differentiation of Metabolic Syndrome-Derived Mesenchymal Stem Cells by Modulating Autophagy.Oxid Med Cell Longev. 2019 May 12;2019:1523140.

CAS Number: 320-67-2

Molecular Weight: 244.20

Compound Purity: 99.94

Research Area: Cancer; Infection

Solubility: DMSO : ≥ 31 mg/mL/H2O : 25 mg/mL (ultrasonic;warming;heat to 60°C)

Target: Antibiotic;Autophagy;Bacterial;DNA Methyltransferase;Nucleoside Antimetabolite/Analog;Organoid

• Artikelnummer: MEXHY-10586-10.1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-10586-10.1
• Verpackungseinheit: 10 mM/1 ml
• Mengeneinheit: STK