5-(N-ethyl-N-isopropyl)-Amiloride, CAS 1154-25-2

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 3-amino-N-(aminoiminomethyl)-6-chloro-5-[ethyl(1-methylethyl)amino]-2-pyrazinecarboxamide

Purity: ≥98%

Formula Markup: C11H18ClN7O

Formula Weight: 299.8

CAS Number: 1154-25-2

Notes: Sodium-hydrogen exchangers (NHE) are involved in maintaining sodium and pH balance in a variety of tissues. They are also known as sodium-hydrogen antiporters and solute carrier family 9 members. 5-(N-ethyl-N-isopropyl)-Amiloride (EIPA) is a potent inhibitor of several NHE isoforms, inhibiting NHE1, NHE2, NHE3, and NHE5 with Ki values of 0.02, 0.5, 2.4, and 0.42 μM, respectively.{22706,22708} It less effectively inhibits NHE4 (IC50 ≥10 μM).{22706} EIPA is commonly used at a concentration of 5-10 μM to inhibit cellular HNE activity.{22705,22707}

• Artikelnummer: CAY14406-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 14406-25
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK