Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 2-(3,4-dimethoxyphenyl)-5-hydroxy-6,7,8-trimethoxy-4H-1-benzopyran-4-one
Purity: ≥98%
Formula Markup: C20H20O8
Formula Weight: 388.368
CAS Number: 2174-59-6
Notes: 5-O-Demethylnobiletin is a flavonoid that has been found in S. tragoriganum and has diverse biological activities.{68078,68079,68080,68081} It induces neurite outgrowth and the expression of the genes encoding the neuronal differentiation and synapse formation markers growth-associated protein 43 (GAP43) and synaptophysin in PC12 cells when used at concentrations ranging from 10 to 20 µM.{68078} 5-O-Demethylnobiletin (2.5-20 µM) reduces triglyceride levels in 3T3-L1 preadipocytes and decreases body weight, intra-abdominal fat, plasma and liver triglyceride levels, and plasma cholesterol levels in a mouse model of high-fat diet-induced obesity when administered at a dose of 25 mg/kg.{68079} It reduces hepatic fibrosis and malondialdehyde (MDA) levels in a mouse model of carbon tetrachloride-induced liver injury.{68080} 5-O-Demethylnobiletin also reduces ear edema, inflammatory cell infiltration, and papillar fibrosis in a mouse model of inflammation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014).{68081}
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