Product Description: 6-Chloro-7-deazaguanine (compound 63) is an inactive molecule of IKK (lacking the critical 5-cyano group), targeting IKKα and IKKβ with Ki values both greater than 30 μM. IKKβ and IKKα are core molecules in the canonical and non-canonical NF-κB pathways, respectively[1].
Formula: C6H5ClN4
References: [1]Anthony NG, Baiget J, Berretta G, Boyd M, Breen D, Edwards J, Gamble C, Gray AI, Harvey AL, Hatziieremia S, Ho KH, Huggan JK, Lang S, Llona-Minguez S, Luo JL, McIntosh K, Paul A, Plevin RJ, Robertson MN, Scott R, Suckling CJ, Sutcliffe OB, Young LC, Mackay SP. Inhibitory Kappa B Kinase α (IKKα) Inhibitors That Recapitulate Their Selectivity in Cells against Isoform-Related Biomarkers. J Med Chem. 2017 Aug 24;60(16):7043-7066.
CAS Number: 84955-31-7
Molecular Weight: 168.58
Compound Purity: 99.83
Research Area: Cancer
Solubility: H2O : 2.5 mg/mL (ultrasonic;warming;heat to 60°C)
Target: IKK
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