666-15, CAS 1433286-70-4

Product Description: 666-15 is a potent and selective CREB inhibitor with an IC50 of 81 nM. 666-15 suppresses tumor growth in a breast cancer xenograft model[1][2].

Applications: Cancer-Kinase/protease

Formula: C33H31Cl2N3O5

References: [1]Xie F, et al. Identification of a Potent Inhibitor of CREB-Mediated Gene Transcription with Efficacious in Vivo Anticancer Activity. J Med Chem. 2015 Jun 25;58(12):5075-87./[2]Zhang B, et al. C1q-TNF-related protein-3 attenuates pressure overload-induced cardiac hypertrophy by suppressing the p38/CREB pathway and p38-induced ER stress. Cell Death Dis. 2019 Jul 8;10(7):520./[3]Qin Y, et al. Interfering MSN-NONO complex-activated CREB signaling serves as a therapeutic strategy for triple-negative breast cancer. Sci Adv. 2020 Feb 19;6(8):eaaw9960.

CAS Number: 1433286-70-4

Molecular Weight: 620.52

Compound Purity: 99.74

Research Area: Cancer

Solubility: DMSO : 125 mg/mL (ultrasonic;warming;heat to 60°C)

Target: Epigenetic Reader Domain

• Artikelnummer: MEXHY-101120-10.1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-101120-10.1
• Verpackungseinheit: 10 mM/1 ml
• Mengeneinheit: STK