680C91, CAS 163239-22-3

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 6-fluoro-3-[(1E)-2-(3-pyridinyl)ethenyl]-1H-indole

Purity: ≥98%

Formula Markup: C15H11FN2

Formula Weight: 238.259723

CAS Number: 163239-22-3

Notes: 680C91 is an inhibitor of tryptophan 2,3-dioxygenase (TDO; IC50s = 1.46 and 0.28 µM for the mouse and human enzymes, respectively).{61677} It is selective for TDO over indoleamine 2,3-dioxygenase (IDO; IC50 = >80 µM for the mouse enzyme). 680C91 (40 µM) inhibits the migration of SK-MEL-28 melanoma cells induced by dexamethasone (Item No. 11015).{61678} It increases brain levels of tryptophan, serotonin (5-HT), and 5-hydroxy indole-3-acetic acid (5-HIAA) in rats in a dose-dependent manner.{61679}

• Artikelnummer: CAY34823-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 34823-25
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK