6α-Hydroxy Paclitaxel-d5, CAS 1315376-90-9

Product Description: 6α-Hydroxy Paclitaxel-d5 is the deuterium labeled 6α-Hydroxy paclitaxel. 6α-Hydroxy paclitaxel is a primary metabolite of Paclitaxel. 6α-Hydroxy paclitaxel retains a time-dependent effect on organic anion–transporting polypeptides 1B1/SLCO1B1 (OATP1B1) with similar inhibition potency to Paclitaxel, whereas it no longer showed time-dependent inhibition of OATP1B3. 6α-Hydroxy paclitaxel can be used for the research of cancer[1].

Formula: C47H46D5NO15

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. /[2]Mori D, et al. Alteration in the Plasma Concentrations of Endogenous Organic Anion-Transporting Polypeptide 1B Biomarkers in Patients with Non-Small Cell Lung Cancer Treated with Paclitaxel. Drug Metab Dispos. 2020 May;48(5):387-394.

CAS Number: 1315376-90-9

Molecular Weight: 874.94

Compound Purity: 99.31

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Isotope-Labeled Compounds

• Artikelnummer: MEXHY-125348S-1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-125348S-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK