7ACC2, CAS 1472624-85-3

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 7-[methyl(phenylmethyl)amino]-2-oxo-2H-1-benzopyran-3-carboxylic acid

Purity: ≥98%

Formula Markup: C18H15NO4

Formula Weight: 309.3

CAS Number: 1472624-85-3

Notes: 7ACC2 is a carboxycoumarin inhibitor of monocarboxylate transporter 1 (MCT1) with an IC50 value of 10 nM for lactate uptake, an MCT1-dependent process, in SiHa human cervix carcinoma cells.{36195} It inhibits proliferation of SiHa cells in the presence of lactate in a dose-dependent manner but lacks cytotoxicity in the presence of glucose. 7ACC2 also inhibits the mitochondrial pyruvate carrier (MPC) in a concentration- and time-dependent manner in isolated tumor cell mitochondria.{46097} In vivo, 7ACC2 (3 mg/kg) increases intratumor lactate accumulation and decreases tumor size in an SiHa mouse xenograft model.

• Artikelnummer: CAY23445-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 23445-25
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK