Product Description: 7DG (7-Desacetoxy-6,7-dehydrogedunin) is a protein kinase R (PKR) inhibitor. 7DG protects macrophages from lethal toxin-induced pyroptosis[1].
Applications: COVID-19-anti-virus
Formula: C26H30O5
References: [1]Hett EC, et, al. Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis. Nat Chem Biol. 2013 Jun;9(6):398-405. /[2]Chukwurah E, et, al. A tale of two proteins: PACT and PKR and their roles in inflammation. FEBS J. 2021 Nov;288(22):6365-6391.
CAS Number: 26927-01-5
Molecular Weight: 422.51
Compound Purity: 98
Research Area: Inflammation/Immunology
Solubility: 10 mM in DMSO
Target: PERK