Product Description: 8-Bromo-cAMP (8-Br-Camp), a cyclic AMP analog, is an activator of cyclic AMP-dependent protein kinase (PKA). 8-Bromo-cAMP has anti-proliferative and apoptotic effects against cancer cells[1][2].
Applications: Cancer-Kinase/protease
Formula: C10H11BrN5O6P
Citations: BMC Biol. 2024 May 3;22(1):104./J Assist Reprod Genet. 2024 Sep 14./Cell Mol Life Sci. 2022 Nov 13;79(12):589./Cell Oncol. 2023 Mar 20./Cell Signal. 2024 Sep 27:111438./EMBO J. 2024 Sep 11./Environ Health (Wash). 2024 Aug 16;2(11):776-785./Hum Reprod. 2021 Jan 1;36(1):145-159./Inflammation. 2022 Jul 7./J Assist Reprod Genet. 2024 Mar 21./J Bone Miner Metab. 2021 May 14./J Hazard Mater. 2024 Jun 7:475:134854./Korean J Pain. 2023 Jul 1;36(3):335-346./Mol Cell Endocrinol. 2023 May 31;111952./Part Fibre Toxicol. 2022 Feb 17;19(1):13./Reprod Biol Endocrinol. 2022 Sep 22;20(1):142./Reprod Sci. 2022 Oct 7./Res Sq. 2024 Sep 09./Research Square Preprint. 2021 Jul/Research Square Preprint. 2021 Jul./Sci Total Environ. 2022 Oct 10;842:156854./SSRN. 2023 Aug 1./Theriogenology. 2022 Jun 19;189:118-126.
References: [1]Wang Y, et al. A cyclic AMP analog, 8-Br-cAMP, enhances the induction of pluripotency in human fibroblast cells. Stem Cell Rev. 2011 Jun;7(2):331-41./[2]Wang HM, et al. Dual effects of 8-Br-cAMP on differentiation and apoptosis of human esophageal cancer cell line Eca-109. World J Gastroenterol. 2005 Nov 7;11(41):6538-42./[3]Baek MO, et al. Differential regulation of mTORC1 and mTORC2 is critical for 8-Br-cAMP-induced decidualization. Exp Mol Med. 2018 Oct 30;50(10):1-11. /[4]Wang S, et al. Angiogenesis and vasculogenic mimicry are inhibited by 8-Br-cAMP through activation of the cAMP/PKA pathway in colorectal cancer. Onco Targets Ther. 2018 Jul 2;11:3765-3774
CAS Number: 23583-48-4
Molecular Weight: 408.10
Compound Purity: 99.41
Research Area: Cancer
Solubility: H2O : 5.74 mg/mL (ultrasonic;warming;adjust pH to 9 with 1 M NaOH;heat to 60°C)
Target: Apoptosis;PKA
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