8-Oxoguanine DNA Glycosylase(CPTC-OGG1-1), CF740 conjugate, 0.1mg/mL

8-Oxoguanine DNA Glycosylase(CPTC-OGG1-1), CF740 conjugate, 0.1mg/mL
Artikelnummer
BTMBNC742251-500
Verpackungseinheit
500 uL
Hersteller
Biotium

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Description: 8-Oxoguanine DNA Glycosylase (OGG1), otherwise known as N-Glycosylase/DNA lyase, is the enzyme responsible for the excision of 8-oxoguanine (8-oxoG), a mutagenic base by-product which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Accumulation of 8-oxoG increases the occurrence of A:T to C:G or G:C to T:A transversion mutations, because 8-oxoG forms a stable basepair with adenine as well as with cytosine. The OGG1 gene encodes eight isoforms (OGG1A-C, OGG2A-E) which result from alternative splicing of a single messenger RNA. The OGG1A splice variant is the most prevalent form and localizes to the nucleus, whereas the OGG2A splice variant is targeted to the mitochondria. Defects in OGG1 may be a cause of renal cell carcinoma. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Product Origin: Animal - Mus musculus (mouse), Bos taurus (bovine)

Conjugate: CF740

Concentration: 0.1 mg/mL

Storage buffer: PBS, 0.1% rBSA, 0.05% azide

Clone: CPTC-OGG1-1

Immunogen: Recombinant full-length human OGG1 protein

Antibody Reactivity: N-Glycosylase/DNA lyase

Entrez Gene ID: 4968

Z-Antibody Applications: IHC, FFPE (verified)

Verified AB Applications: IHC (FFPE) (verified)
Mehr Informationen
Artikelnummer BTMBNC742251-500
Hersteller Biotium
Hersteller Artikelnummer BNC742251-500
Verpackungseinheit 500 uL
Mengeneinheit STK
Reaktivität Human
Klonalität Monoclonal
Methode Immunohistochemistry
Isotyp IgG2c kappa
Wirt Mouse
Konjugat Conjugated, CF740
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