Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 6,7-dihydro-4H-bis[1,3]benzodioxolo[5,6-a:4',5'-g]quinolizin-4-one
Purity: ≥98%
Formula Markup: C19H13NO5
Formula Weight: 335.31026
CAS Number: 19716-61-1
Notes: 8-Oxycoptisine is an isoquinoline alkaloid that has been found in Coptis chinensis and has anticancer and gastroprotective activities.{61590,61591,61592} It is an active metabolite of coptisine (Item No. 28424) formed by gut microbiota.{61590} 8-Oxycoptisine is cytotoxic against NCI-N87 gastric, but not Caco-2 colon, cancer cells (IC50s = 20.31 and >100 µM, respectively).{61591} It reverses resistance to paclitaxel (Item No. 10461) in non-multidrug-resistant SKOV3 cells, as well as in HCT-15 cells, which endogenously express high levels of P-glycoprotein (P-gp), with EC50 values of 0.3 and 0.5 ng/ml, respectively.{61592} It reduces colonic shortening and inflammatory cell infiltration in a mouse model of ulcerative colitis induced by dextran sulfate (DSS; Item No. 23250) when administered at doses of 50 or 100 mg/kg.{61590}
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