9-ING-41, CAS 1034895-42-5

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 3-(5-fluoro-3-benzofuranyl)-4-(5-methyl-5H-1,3-dioxolo[4,5-f]indol-7-yl)-1H-pyrrole-2,5-dione

Purity: ≥98%

Formula Markup: C22H13FN2O5

Formula Weight: 404.4

CAS Number: 1034895-42-5

Notes: 9-ING-41 is an inhibitor of glycogen synthase kinase 3β (GSK3β; IC50 = 0.71 µM).{69003} It inhibits the growth of MiaPaCa-2, BxPC-3, and HuP-T3 pancreatic cancer cells (IC50s = 5, 1, and 0.6 µM, respectively). 9-ING-41 (5 µM) inhibits GSK3β phosphorylation and induces apoptosis in BxPC-3 and HuP-T3 cells. In vivo, 9-ING-41 (40 mg/kg) reduces tumor growth in an SKOV3 mouse xenograft model.{69004} It also reduces pleural thickening and improves lung function in a mouse model of S. pneumoniae-induced empyema.{69005}

• Artikelnummer: CAY36629-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36629-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: Reinstoffe